Hazzard's Geriatric Medicine & Gerontology, 6th Edition by Jeffrey B. Halter, Joseph G. Ouslander, Mary Tinetti,

By Jeffrey B. Halter, Joseph G. Ouslander, Mary Tinetti, Stephanie Studenski, Kevin P. High, Sanjay Asthana

The such a lot whole, authoritative advisor to be had at the prognosis and remedy of issues affecting the aged -- up-to-date with a brand new international perspective

A Doody's middle identify for 2015!

"In addition to serving as a well timed, complete, state of the art textbook of geriatric drugs anchored in technological know-how, evidence-based medication, and patient-centered perform, the e-book is also meant to satisfy the training wishes of men in geriatric medication. The authors achieve modeling a textbook of geriatric drugs on textbooks of inner medication. three Stars."--Doody's evaluate Service

The undisputed chief just about geriatrics, this accomplished advisor combines gerontology ideas with scientific geriatrics delivering unequalled insurance of this sector of medicine.

Written through a number of the world's Most worthy geriatricians, Hazzard's rules of Geriatric drugs and Gerontology provides the main up to date, evidence-based clinical details to be had -- in a made over 2-color layout that makes discovering the solutions for your questions quicker and more straightforward than ever.

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  • A higher emphasis on evidence-based drugs in the course of the improved use of medical perform guidance and references to systematic studies and seriously appraised topics
  • A new overseas advisory board of 12 international professionals and an elevated variety of overseas participants for a better international perspective
  • Important new chapters at the cultural facets of geriatrics, emergency geriatrics, medical institution geriatrics, foreign geriatric care, and rural geriatric care
  • Information built-in with extra on-line resources
  • Tables, drawings, and medical algorithms made much more powerful through a brand new two-color layout
  • 300 illustrations (including sixty four in a full-color insert)

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Hazzard's Geriatric Medicine & Gerontology, 6th Edition (Principles of Geriatric Medicine & Gerontology)

The main entire, authoritative consultant to be had at the analysis and remedy of issues affecting the aged -- up to date with a brand new international perspectiveA Doody's center name for 2015! "In addition to serving as a well timed, accomplished, cutting-edge textbook of geriatric drugs anchored in technology, evidence-based medication, and patient-centered perform, the publication is also meant to satisfy the educational wishes of guys in geriatric medication.

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Extra resources for Hazzard's Geriatric Medicine & Gerontology, 6th Edition (Principles of Geriatric Medicine & Gerontology)

Sample text

Similarly, lifespan and mortality risks are influenced by many factors besides aging. Thus, evidence that a gene or diet or public health measure has altered life expectancy, upwards or downwards, does not imply that the effects have been achieved by an effect on aging. In the context of the whole organism definition of aging used in this chapter, it is hard to interpret the meaning of changes that occur as individual cells “age” in tissue culture. While cell culture studies can provide valuable information of great relevance to ideas about aging, the two processes are likely to be fundamentally different.

Furthermore, an unknown but potentially large fraction of this genetic variation probably reflects genetic variants that influence susceptibility to diseases of childhood, infectious agents, and specific common illnesses of old age. For example, genetic variants that cause Huntington’s disease or type 1 diabetes or which triple the normal risk of myocardial infarction by the age of 50 years would all contribute to the measured heritability of lifespan, but do so by altering mortality risks from a specific form of illness rather than by alteration of aging with its effects on multiple late-life traits.

Mice in which tissue levels of IGF-I are reduced by genetic manipulation of a protease that controls local concentrations of IGF-I binding proteins are also long-lived, again consistent with models in which abnormally low IGF-I levels cause lifespan extension in mice. Studies of Snell and Ames dwarf mice have shown that the exceptional longevity of these mice is accompanied by a delay or deceleration of age-dependent changes in T lymphocytes, skin collagen, renal pathology, lens opacity, cognitive function, and neoplastic progression; taken with the lifespan data, these observations suggest strongly that these mutations, like the CR diet, act to slow the aging process itself.

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