Extreme Medicine: How Exploration Transformed Medicine in by Kevin Fong

By Kevin Fong

Little a couple of hundred years in the past, maps of the realm nonetheless boasted white house: locations the place no human had ever trod. inside a number of brief many years the main adversarial of the world's environments had all been conquered. Likewise, within the 20th century, drugs remodeled human lifestyles. medical professionals took what used to be regularly deadly and made it survivable. As modernity introduced us ever extra into other kinds of extremes, medical professionals driven the limits of scientific advances and human persistence. severe exploration challenged the physique in ways in which simply the forefront of technological know-how may resolution. medical professionals, scientists, and explorers all percentage a defining trait: they push on within the face of grim odds. due to their severe exploration we not just comprehend our body structure larger; we've additionally made huge, immense strides within the technology of healing.

Drawing on his personal event as an anesthesiologist, in depth care professional, and NASA adviser, Dr. Kevin Fong examines how state of the art medication pushes the envelope of human survival via learning the human body's reaction while established by means of actual extremes. Extreme Medicine explores various limits of patience and the lens each one bargains on one of many structures of the physique. The demanding situations of Arctic exploration created possibilities for breakthroughs in open middle surgical procedure; battlefield medical professionals pioneered ideas for pores and skin grafts, center surgical procedure, and trauma care; underwater and outer house exploration have revolutionized our realizing of respiring, gravity, and masses extra. Avant-garde medication is essentially altering our principles in regards to the nature of existence and death.

Through fabulous bills of remarkable occasions and pioneering medication, Fong illustrates the sheer audacity of clinical perform at severe limits, the place human existence is balanced on a knife's facet. Extreme Medicine is a gripping debut in regards to the technological know-how of therapeutic, but additionally approximately exploration in its broadest sense—and approximately how, by way of probing the very limits of our biology, we may perhaps finally go back with a greater appreciation of the way bodies paintings, of what lifestyles is, and what it ability to be human.

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REFERENCES 1. McKay RG. Catheter-based techniques of local drug delivery. In Freed M, Grines C, Safian RD (eds), The New Manual of Interventional Cardiology. Physicians Press: Birmingham, MI 1996:645–60. 2. Kipshidze NN, Kim HS, Iverson P, et al. Intramural coronary delivery of advanced oligonucleotides reduces neointimal formation in the porcine stent restenosis model. J Am Coll Cardiol 2002; 39(10):1686–91. 3. Logeart D, Hatem S, Ruecker-Martin C, et al. Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery Hum Gene Ther 2000; 11:1015–22.

This low pressure technique does not overextend or damage the vessel wall and it allows for treatment of native vessels, stented vessels, and synthetic grafts. Fig. 1 The porous microarchitecture of expanded polytetrafluoroethylene (ePTFE). 2. The tortuous The ClearWay™ microporous balloon catheter 29 channels of ePTFE do not allow for a direct fluid path to the surface, and this prevents the damage-inducing ‘jetting’ effect. The rate of fluid flow can be controlled by the amount of pressure applied by the operator.

Fig. 2 Details of the Dispatch® catheter balloon design. The Dispatch® is an over-the-wire catheter that consists of a spiral inflation coil wrapped around a nonporous polyurethane sheath. When the spiral coil is inflated, it forms both an Local drug delivery for coronary artery disease 40 internal conduit that allows continued blood flow in the artery and a series of isolated drug spaces. Drugs are delivered through the infusion port and enter the delivery spaces through the isolated infusion openings on the balloon surface.

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