Epilepsy: Animal and Human Correlations by David W. McCandless

By David W. McCandless

The current quantity is meant to be a synopsis of seizure issues with a target of describing key stories in animals and people. the interpretation of pertinent findings from animal stories to human reviews, and to power human reviews should be emphasised. particular cogent animal studies/results which deserve exploration in human seizure issues can be specified. the present cost of translation is predicted to be from 7‐9 years, and the “success” expense of translation used to be very lately indexed as below one part. The luck price is outlined as ends up in human reviews that have been expected upfront through animal experiences. either the time among animal and human makes an attempt plus the luck price desire development.

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Additional resources for Epilepsy: Animal and Human Correlations

Sample text

In one study (Dawson et al. 1951) of 45 patients with severe brain trauma, 24% had EEG evidence of seizures after 1 week following the trauma. The authors of this current paper (Vespa et al. 1997) reported a very similar result (21%) as regards posttrauma epilepsy. Risk factors include young age (under 5 years of age), diffuse edema, the presence of subdural hematoma, and coma. Penetrating brain injuries such as gunshot victims may have an epilepsy incidence rate of over 40%. The authors (Vespa and Nuwer) note that the identification of posttraumatic epilepsy may be difficult in part because of the low age of many patients.

Stroke may be the main cause of epilepsy in the elderly (Schreiner et al. 1995), who emphasize the importance of vigorous definitions is critical. In clinical settings, there is a wide variation in reports of incidence, varying between 1 and 25% of stroke patients. Reasons for the variation include use of nonstandard definitions, case ascertainment, a wide variation in the reports of the seizure witnesses, inclusion in studies of patients with TIAs, who almost never have seizures, etc. 9% of patients had seizures at a 9-month follow-up (Bladin et al.

This study illustrates the highly complicated and difficult problems which can be encountered in trying to provide epilepsy care to developing areas. Nevertheless, there were positive achievements, and not trying is no option. Chapter 2 Metabolism and Epilepsy This chapter will examine some aspects of the metabolic (especially energy metabolism) and pharmacologic responses to epileptic seizures. This involves animal models as well as imaging studies in patients. Some results are in conflict, and this is probably linked to the usual differences in methodology, and in definitions and data interpretation.

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