By Howard M. Fillit MD
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Additional info for Drug Discovery and Development for Alzheimer s Disease
There were 95 participants who were given the OMC test. All but seven (93%) scored >24 (fewer than four errors). Only three participants scored in the impaired range of <24. Among the three scoring below 24 on the OMC, one stated that she had had a stroke, one stated that she had Parkinson's disease and was being followed by a neurologist, and one stated that Slovak was her native language. None of these participants had a diagnosis of dementia in the diagnostic codes stored in their electronic medical record.
9% coefficient of variation, then the number of MCI patients needed to produce sufficient power to find a significant effect would be 30. 01. 6th percentile of the control's standard normal distribution) (Cohen, 1988). Sensitivity (true positives / (true positives + false negatives) and specificity (true negatives / (false positives + true negatives) calculations were also computed for each method's ability to correctly identify incipient AD, MCI, and controls. c Berg, L. (1988). Clinical dementia rating.
1, along with the number of MCIs and controls to be studied. c he m 4a ll. Subjects. Both normal controls (n = 30) obtained randomly from the community and MCI patients (n = 30), 15 of whom are known to have incipient AD based upon longitudinal follow-up, were identified based on performance on psychometric testing. The definition of MCI across centers was that of Petersen et al. (1999). 5. The participants were free of cortical infarcts and significant subcortical high-signal abnormalities on T2 MRI.