Biosynthetic Products for Cancer Chemotherapy: Volume 2 by George R Pettit, Gordon M Cragg

By George R Pettit, Gordon M Cragg

An total view of the melanoma challenge and improvement of melanoma chemothera­ 231 peutic biosynthetic items to February 1976 was once awarded in quantity 1. within the short while that has elapsed because the guidance of quantity 1, a number of very stimulating advances in software of biosynthetic melanoma chemotherapeutic medications in melanoma therapy were mentioned. on the may possibly 1976 assembly (in Toronto) of the yank organization for melanoma study, a Sloan-Kettering examine workforce summarized a higher therapy of human neuroblastoma utilizing a mixture of vincristine, cytoxan, trifluorothymidine, and papaverine. within the related interval different medical teams defined major advances within the melanoma chemotherapeutic remedy of human breast melanoma and oat phone carcinoma of the lung. each one of those more moderen advances in melanoma remedy was once in line with combos of biosynthetic and artificial melanoma chemotherapeutic medications. definitely, additional exam of the antineoplastic biosynthetic brokers summarized during this quantity and the sizeable quantity but to be came upon will finally give you the potential for controllil).g and/or curing a number of the different types of human cancer.

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5,ug/ml MELTING POINT: 208-21O°C HO [aID: +65 SOLVENT: An SPECTRAL DATA: UV, IR, PMR. Mass Spec ORGANISM: Vernania amygdalina DeI. (Compositae) LOCATION: Ethiopia REFERENCE: ISO MOL. : BIOACTIVITY: Eriolanin 350 P388: Sign. act. 5-128°C [aID: -93 SOLVENT: Chf SPECTRAL DATA: PMR, Mass Spec ORGANISM: Eriophyllum lanatum (Compositae) REFERENCE: 132 MOL. 12 ,ug/ml MELTING POINT: 226-230°C ORGANISM: Baileya multiradiata (Compositae) LOCATION: Arizona, 1966 REFERENCE: 238 MOL. 28 ,ug/ml WA: T/C, 12 (100 mg/kg) MELTING POINT: 242-244°C HJC raID: -380 SOLVENT: Chr SPECTRAL DATA: UV, IR, PMR, Mass Spec ORGANISM: Elephantopus elatus Bertol.

Taxodiaceae) LOCATION: Maryland REFERENCE: 154 MOL. 29 ,ug/ml PS: Sign. act. MELTING POINT: Amorphous foam [aID: + 75 SOLVENT: Me SPECTRAL DATA: UV, IR, PMR, Mass Spec ORGANISM: Eupatorium semiserratum (Compositaej LOCATION: Florida REFERENCE: 146 MOL. ug/m1 PS: T/C, 141 (100 mg/kg) MELTING POINT: 259-261°C ORGANISM: Baileya multiradiata (Compositae) LOCATION: Arizona REFERENCE: 238 MOL. : CH J : 0 BIOACTIVITY: /~ ...... ug/m1 WA: T/C, 9 (25 mg/kg) MELTING POINT: 164-165°C [a]D: +50 SOLVENT: Chf SPECTRAL DATA: UV, IR, PMR, Mass Spec ORGANISM: Taxodium distichum Rich.

OOI,ug/ml Sign. aet. in LE and PS MELTING POINT: 226-227°C [a]D: -154 SOLVENT: Dem SPECTRAL DATA: UV, IR, PMR, Mass Spee ORGANISM: Trypterygium wilfordii (Celastraeeae) LOCATION: Taiwan REFERENCE: 140 MOL. 21,ug/ml MELTING POINT: 199-200°C [a]D: -124 SOLVENT: Ale SPECTRAL DATA: UV, IR, PMR, Mass Spee ORGANISM: Eupatorium rotundifolium L. (Compositae) LOCATION: Florida REFERENCE: 155 MOL. : BIOACTIVITY: o .. ug/m1 MELTING POINT: 188-189°C [aID: -80 SOLVENT: Ale SPECTRAL DATA: UV,IR,PMR ORGANISM: Eupatorium rotundifolium L.

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