By B. Beek
The bioaccumulation of endocrine disruptors, chronic natural chemical compounds and different compounds of excessive environmental effect has develop into of accelerating curiosity in most modern environmental study, hazard research and toxicology. This quantity supplies an updated evaluation and introduces the reader to the recent proposal of "internal influence focus" linking bioaccumulation and biomagnification within the meals chain to ecotoxicology and danger overview.
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It is important to note that some synthetic estrogens, such as diethylstilbestrol (DES), moxestrol, and 11b-chloromethyl estradiol show 10 times more estrogenic activity than 17b-estradiol in the E-SCREEN assay . Ethinylestradiol has the same estrogenic activity as 17b-estradiol, whereas the activity of the synthetic EDCs is by some orders of magnitude lower . In this context it is important to note that most, if not all, efflu- Bioaccumulation and Occurrence of Endocrine-Disrupting Chemicals (EDCs) 37 ents of sewage treatment plants [145 b] and some rivers [145 c] in the United Kingdom are estrogenic to fish.
232c]. Measured by Nakagawa et al. [232d]. BCF value of 14C-3,4-DCA in three-spined stickleback [232e]. Worst-case BCFL value for fish predicted from the log Kow value if no metabolism occurs or is negligible. J. Geyer et al. Recently, it was found by Kelce et al. [125a] that the persistent p,p¢-DDT metabolite p,p¢-DDE is a potent androgen receptor antagonist. This compound is highly hydrophobic and has a very high bioconcentration potential. Furthermore, it is important to note that also estrogens, such as estradiol, diethylstilbestrol, Kepone, o,p¢-DDT, and methoxychlor can bind also to the androgen receptor [125b].
They found also no synergism. It is important to note that very recently McLachlan et al. [145 a] have just formally withdrawn their report. In his laboratory the coworkers have conducted experiments duplicating the conditions of their earlier work, but were unable to replicate their original results. The natural female steroid hormone with the greatest estrogenic activity is 17ß-estradiol. It is important to note that some synthetic estrogens, such as diethylstilbestrol (DES), moxestrol, and 11b-chloromethyl estradiol show 10 times more estrogenic activity than 17b-estradiol in the E-SCREEN assay .