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Cold Spring Harb Symp Quant Biol 1989;54(Pt 1):1–13. 2 Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000;18: 767–811. P1: SFK/UKS BLBK416-c02 P2: SFK Color: 1C BLBK416-Morrow May 15, 2012 7:23 Trim: 246mm X 189mm Printer Name: Yet to Come Chapter 2: Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 3 Adams S, O’Neill DW, Bhardwaj N. Recent advances in dendritic cell biology. J Clin Immunol 2005; 25(3):177–88. 4 Dieu MC, Vanbervliet B, Vicari A, et al.
Type I interferons keep activated T cells alive. J Exp Med 1999; 189(3):521–30. 85 Zhang J, Tachado SD, Patel N, et al. Negative regulatory role of mannose receptors on human alveolar macrophage proinﬂammatory cytokine release in vitro. J Leukoc Biol 2005;78(3):665–74. 86 Shibata Y, Metzger WJ, Myrvik QN. Chitin particleinduced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. J Immunol 1997;159(5):2462–7. 87 Sturge J, Todd SK, Kogianni G, McCarthy A, Isacke CM.
HLA-DM can catalyze the release of peptides that do not enhance or allow class II molecules to attain appropriate stability  and is thought to act by a “compare and exchange” mechanism . 5). Peptide acquisition and presentation by MHC class II molecules can occur throughout the endocytic pathway. The intersection point between newly synthesized MHC class II molecules and the endocytic location of their peptide acquisition occurs within a distinct cellular compartment known as the MHC class II compartment (MIIC) [68–70].