Ageing: Lessons from C. elegans by Anders Olsen, Matthew S. Gill

By Anders Olsen, Matthew S. Gill

This publication brings jointly in a single quantity the present country of getting older study within the nematode Caenorhabditis elegans. The authors are major researchers within the box, putting this subject within the context of human growing old, describing how and why easy discoveries during this uncomplicated organism have impacted our customers for intervention within the getting older method. The authors disguise a extensive variety of themes just about organismal and reproductive getting old together with anatomical, physiological and biochemical alterations, in addition to genetic and environmental interventions that advertise durability and ameliorate age-related sickness. growing old is the one most crucial issue picking out the onset of human ailment in constructed international locations. With present all over the world demographic traits indicating that the variety of members over the age of sixty five will proceed to upward thrust, it truly is transparent that an realizing of the tactics that underpin getting older and age-related sickness represents a key problem within the biomedical sciences. lately there were large advances in our realizing of the growing older strategy and plenty of of those have stemmed from genetic research of C. elegans.

With no analogous ebook during this topic sector this paintings may be of curiosity to a large viewers, starting from educational researchers to the final public.

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Extra resources for Ageing: Lessons from C. elegans

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Several endocrine signals have been identified that regulate dauer formation and most of them emanate from the sensory neurons. The guanylyl cyclase encoded by daf-11 is expressed in ASI and other chemosensory neurons and is thought to be involved in second messenger signalling downstream of chemosensory signalling that leads to secretion of insulin and TGF-β neuropeptides [44, 45]. daf-11 mutants are strongly Daf-c [44] and are suppressed by Daf-d mutants with defective chemosensory cilia [46].

10). The intestine is not directly innervated and has only one associated muscle (the stomatointestinal muscle) at its posterior extreme. Intestinal cells are large and cuboidal with distinct apical, lateral and basal regions (Fig. 10b). Intestinal cells contain one or often two large nuclei with prominent nucleoli, many mitochondria, extensive rough endoplasmic reticulum, many ribosomes and an extensive collection of membrane-bound vesicles and vacuoles. Adherens junctions seal each intestinal cell to its neighbours on the apical side and gap junctions and septate-like junctions connect them on the lateral sides (Fig.

Exp Gerontol 15(4):285–289 12. Glenn CF, Chow DK, David L, Cooke CA, Gami MS, Iser WB, Hanselman KB, Goldberg IG, Wolkow CA (2004) Behavioral deficits during early stages of aging in C. elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol 59(12):1251–1260 2 Effects of Ageing on the Basic Biology and Anatomy of C. elegans 37 13. Huang C, Xiong C, Kornfeld K (2004) Measurements of age-related changes of physiological processes that predict lifespan of C. elegans. Proc Natl Acad Sci USA 101(21):8084–8089 14.

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