By Gordon Guyatt, Drummond Rennie, Maureen O. Meade, Deborah J. Cook
The best consultant to the rules and scientific purposes of evidence-based drugs.
Read Online or Download A Manual for Evidence-Based Clinical Practice (3rd Edition) (Users' Guides to the Medical Literature) PDF
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Extra resources for A Manual for Evidence-Based Clinical Practice (3rd Edition) (Users' Guides to the Medical Literature)
2 This provides the philosophical basis for the second principle of EBM: not all evidence is equal (Box 3-1). In this book, we offer guidance for determining more vs less credible evidence (see Chapter 2, What Is Evidence-Based Medicine? and Chapter 23, Understanding and Applying the Results of a Systematic Review and Meta-analysis). Evidence Is Necessary but Not Sufficient for Clinical Decision Making As highlighted above, EBM has emerged as a result of our hunger for evidence or information9 to guide problem solving and decision making.
1992;268(2):240-248. Nisbett R, Ross L. Human Inference. Englewood Cliffs, NJ: Prentice-Hall; 1980. 4. Guyatt G, Sackett D, Taylor DW, Chong J, Roberts R, Pugsley S. Determining optimal therapy—randomized trials in individual patients. N Engl J Med. 1986;314(14):889-892. 5. Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT. The n-of-1 randomized controlled trial: clinical usefulness: our three-year experience. Ann Intern Med. 1990; 112(4):293-299. Larson EB, Ellsworth AJ, Oas J.
Why? The right side of the figure displays current reviews and textbook recommendations as data accumulated. ” Two key points: (1) at the same time, experts disagreed, and (2) it took 10 years for experts to catch up with evidence. 2 once again see widespread disagreement among the experts, most texts and reviews were recommending prophylactic lidocaine during the 2 decades during which the RCT evidence was accumulating. Why the expert disagreement, the lag behind the evidence, and the recommendations inconsistent with the evidence?